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Medchemexpress LLC L-Prolinamide, N-[2-[3-[4-[3-[4-[[5-bromo-4-[[3-[(cyclobutylcarbonyl)methylamino]propyl]amino]-... | 2052306-13-3 | 98.2% | 1093.18 g/mol | C53H74BrN9O9S | 5 MG
SDP

Supplier:  Medchemexpress LLC HY1125575MG

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PROTAC TBK1 degrader-2 is a small-molecule PROTAC that binds and induces degradation of TANK-binding kinase 1 (TBK1). It shows potent biochemical and cellular activity and is intended for target validation and mechanism-of-action studies in research settings.

  • Potent degradation of TBK1 (DC50 = 15 nM).
  • High binding affinity to TBK1 (Kd = 4.6 nM).
  • Low-nanomolar inhibitory activity (IC50 TBK1 = 1.3 nM; IKKε = 8.7 nM).
  • High reported purity suitable for research (98.2%).
  • White to off-white solid with good DMSO solubility (110 mg/mL).
  • Intended for cellular and biochemical PROTAC studies and target validation.

Catalog No. 50-002-64323


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