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Cayman Chemical LactosylcRamID nd GnglIos 1mL
SDP

Supplier:  Cayman Chemical 293611 ML

Encompass_Preferred

An FXR agonist (EC50 193 nM in a reporter assay) selective for FXR over the glucocorticoid androgen mineralocorticoid and progesterone receptors in HEK293 cells overexpressing the human receptors (EC50s 10 UM for all in a radioligand binding assay) increases the interaction between FXR and SRC-1 (EC50 121 nM in a cell-free assay) reduces plasma triglyceride and total cholesterol levels in LDL receptor-null mice (ED50s 3 4 and 2 mg/kg respectively) decreases plasma LDL and increases HDL levels in ZDF rats at 3 10 and 30 mg/kg for nine days

Catalog No. 50-299-0035


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