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AdipoGen LAG-3 (human):Fc (human) (rec.),Protein.
Supplier: AdipoGen AG40B0031C050
LAG-3 (human):Fc (human) (rec.), AdipoGen Life Sciences. Protein. The sequence coding for the 4 extracellular Ig-like domains of human LAG-3 (D1-D4) is fused to the Fc portion of human IgG1. Source: CHO cells. Endotoxin content: <0.1EU/?g purified protein (LAL test; Lonza). Liquid. In PBS. Binds to human, mouse and monkey MHC class II. Purity: >99% (SDS-PAGE). Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.
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