LAG3 Detection Set, ProSci

Catalog No.	Quantity
16-595-325	1 Set

Catalog No. 16-595-325 Supplier ProSci LLC Supplier No. SD8700SET

Description

Llama Monoclonal Detection Sets

LAG3 Monoclonal specifically detects LAG3 in Human samples. It is validated for ELISA, IHC-P, IF, Flow

The lymphocyte activation gene-3 (LAG3) is a member of the immunoglobulin superfamily and binds MHC class II with high affinity (1), negatively regulating T-cell function and homeostasis (2). It is expressed in B, T, and NK cells, monocytes, and dendritic cells (3), and acts to regulate T cell expansion (4). LAG3 is also an important immune checkpoint protein, with anti-LAG3 antibodies activating T effector cells and affecting regulatory T cell functions. Furthermore LAG3 appears to act in a synergistic fashion with PD-1/PD-L1, suggesting that a dual antibody approach may prove useful in cancer immunotherapy.

Specifications

• Antigen: LAG3
• Applications: ELISA, Immunohistochemistry (Paraffin), Immunofluorescence, Flow Cytometry
• Concentration: Antibody 1 mg/mL
• Conjugate: Unconjugated
• Formulation: LAG3 Antibodies are supplied in PBS.
• Host Species: Llama
• Immunogen: LAG3 antibodies were raised against a recombinant protein corresponding to amino acids 23-434 of human LAG3.
• Purification Method: LAG3 Antibodies are affinity chromatography purified via Nickel column. Antibodies are supplied as a His-tagged purified protein. They also contains a myc-tag for detection.
• Quantity: 1 Set
• Primary or Secondary: Primary
• Target Species: Human
• Content And Storage: LAG3 antibodies should be stored in working aliquots at -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Product Type: Detection Sets
• Form: Liquid