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Description
Laminin, an extracellular matrix (ECM) multidomain trimeric glycoprotein, was initially isolated from mouse Engelbreth-Holm-Swarm (EHS) tumor (laminin-1). Laminins associate with type IV collagen via entactin and perlecan and bind to cell membranes through integrin receptors, dystrogylcan glycoprotein complex and Lutheran blood group glycoprotein. Laminin has active domains for collagen binding, cell adhesion, heparin binding, and neurite outgrowth fragment.
Laminin (approximately 1 × 106 daltons) is a cell adhesion factor.
- Useful in culturing cells on glass or plastic
- Significantly facilitates the culture of epithelial and endothelial cells
- Supports growth and differentiation of many cell types, including epithelial, endothelial, neural, muscle, and liver cells
Specifications
Specifications
| Formulation | Supplied in 0.05M TRIS; 0.15M NaCl; pH 7.4 |
| Name | Laminin |
| Quantity | 1 mg |
| Source | Mouse EHS Sarcoma |
| Storage Requirements | Store at -70°C. |
| Form | Frozen |
| Purity or Quality Grade | 95+% pure by SDS-PAGE |
Safety and Handling
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