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Apexbio Technology LLC Laquinimod (ABR-215062) 248281-84-7 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A84595.1
Laquinimod (ABR-215062 CAS 248281-84-7) is an orally bioavailable immunomodulatory small molecule Research studies demonstrate that in experimental autoimmune encephalomyelitis (EAE) a widely utilized rodent model for studying human multiple sclerosis (MS) laquinimod treatment suppresses disease progression in a dose-dependent manner Mechanistically the compound reduces inflammatory infiltration of CD4 T lymphocytes and macrophages into the central nervous system thereby modulating the Th1/Th2 immune response and inducing regulatory cytokines such as TGF- Clinical investigations into relapsing MS indicate that laquinimod administration correlates with reduced disease activity clinical relapse rate MRI-measured lesions and brain volume loss
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