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Medchemexpress LLC Larotrectinib | 1223403-58-4 | 99.9% | 10 MG
Supplier: Medchemexpress LLC HY1286610MG
Larotrectinib is an ATP-competitive oral, selective inhibitor of the tropomyosin-related kinase (TRK) family receptors. It demonstrates low nanomolar 50% inhibitory concentrations against all three isoforms (TRKA, B, and C) and exhibits 1,000-fold or greater selectivity relative to other kinases. This product is for research use only.
- Targets TrkA, TrkB, and TrkC
- Exhibits antiproliferative activity against various cell lines
- Demonstrates dose-dependent inhibition of cell proliferation
- Has low brain penetration in animal studies
- Well tolerated in GLP toxicology studies
- Reduces tyrosine phosphorylation of TRKA and downstream signal transduction in tumors
- Shows dose-dependent tumor inhibition in athymic nude mice
- Reduces leukemic infiltration in bone marrow and spleen in mice
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