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Cayman Chemical Latnoprost AChE Tracer 500dtn
Supplier: Cayman Chemical 416810500 DTN
A multi-kinase inhibitor inhibits VEGFR2 PDGFRB FLT3 and c-Kit (IC50s 1.12 0.13 0.63 and 0.14 nM respectively) and is selective for these kinases over RET and AMPKa1 (IC50s 74.1 and 352.2 nM respectively) inhibits VEGF-induced proliferation of HUVECs (IC50 31 nM) decreases VEGF-induced capillary tube formation in HUVECs at 1 UM reduces FBS-induced migration of HUVECs at 0.01 or 0.1 UM reduces tumor volume and growth alone and in combination with gefitinib in an HCC827 NSCLC mouse xenograft model at 80 mg/kg per day
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