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Enzo Life Sciences Lavendustin A (5mg). CAS: 125697-92-9
Supplier: Enzo Life Sciences BMLEI1850005
Cell permeable tyrosine kinase inhibitor with little effect on cAMP-dependent protein kinase (PKA) or protein kinase C (PKC). Potent and selective inhibitor of the EGF receptor tyrosine kinase (IC50=11nM). Binds to a site on the kinase which is distinct from the ATP and peptide substrate binding sites. Inhibits EGF-induced proliferation of cultured human myometrial smooth muscle cells and suppresses VEGF-induced angiogenesis in rats. Effective at 10µM in cultured leech neurons. Also inhibits NMDA-stimulated cGMP production. Alternative name: 5-Amino-[(N-2,5-dihydroxybenzyl)-N'-2-hydroxybenzyl]salicylic acid, RG14355. Purity: ≥95% (HPLC). Solubility: Soluble in DMSO or ethanol. Long Term Storage: -20°C.
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