Apexbio Technology LLC LDC000067 1073485-20-7 10mM (in 1mL DMSO)

Supplier:  Apexbio Technology LLC B47545.1

LDC000067 (CAS 1073485-20-7) also known as LDC067 is a selective inhibitor of cyclin-dependent kinase 9 (CDK9) CDK9 partners with cyclin T to form positive transcription elongation factor b (P-TEFb) which regulates RNA polymerase II by phosphorylating its C-terminal domain thus controlling gene transcription elongation LDC000067 inhibits CDK9 activity with an IC50 of approximately 44 10 nM Compared to other CDKs LDC000067 demonstrates notable selectivity showing 55-fold higher specificity against CDK2 and over 230-fold greater selectivity relative to CDK6 and CDK7 By selectively blocking CDK9 this ATP-competitive inhibitor reduces cellular transcription of short-lived mRNAs associated with proliferation and apoptosis such as MYC and MCL1 Thus LDC000067 is applicable in transcription regulation and cancer-related pathway studies

Catalog No. 50-000-63633