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Apexbio Technology LLC LDE225 (NVP-LDE225,Erismodegib) 956697-53-3 200mg
Supplier: Apexbio Technology LLC B2266200
LDE225 (NVP-LDE225 Erismodegib CAS 956697-53-3) is a small molecule antagonist of the Smoothened (Smo) receptor a central component in the Hedgehog (Hh) signaling pathway implicated in oncogenic processes Identified through cell-based high-throughput screening of combinatorial libraries LDE225 demonstrates potent inhibition of Smo with IC50 values of 1 3 nM in murine models and 2 5 nM in human systems Preclinical studies showed marked suppression of tumor growth in medulloblastoma xenograft mouse models following oral administration with evidence of blood-brain barrier permeability LDE225 is widely used for investigating Hh pathway modulation and its role in cancer research
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