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Apexbio Technology LLC LDN-193189 1062368-24-4 5mg
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Supplier:  Apexbio Technology LLC A83245

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LDN-193189 (CAS 1062368-24-4) is a selective small molecule inhibitor targeting type I bone morphogenetic protein (BMP) receptors specifically activin receptor-like kinase-2 (ALK2) and ALK3 It inhibits ALK2 and ALK3 with IC50 values of approximately 5 nM and 30 nM respectively In vitro studies using C2C12 cells demonstrated that LDN-193189 suppresses BMP-induced phosphorylation of Smad1/5/8 as well as p38 MAPK and Akt signaling Additionally research using bronchial epithelial (Beas2B) cells and murine models indicates that LDN-193189 prevents BMP2-induced E-cadherin downregulation and maintains epithelial barrier integrity LDN-193189 is thus valuable for studying BMP-mediated signaling pathways and related physiological processes

Catalog No. 50-000-61984


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