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Reprocell LDN-193189 IN SOLUTION

Supplier:  Reprocell 04007402

Encompass

Stemolecule LDN-193189 in Solution. LDN-193189 is a cell permeable small molecule inhibitor of bone morphogenetic protein (BMP) type I receptors ALK2 and ALK3 (IC50 = 5 nM and 30 nM respectively)1. LDN-193189 was derived from structure-activity relationship studies of Dorsomorphin and functions primarily through prevention of Smad1, Smad5, and Smad8 phosphorylation1-3. LDN-193189 only weakly inhibits ALK4, ALK5, and ALK71. BMP signaling coordinates developmental patterning and has essential physiological roles in mature organisms4,5. LDN-193189 has been used to reduce ectopic ossification in a mouse model of fibrodysplasia ossificans progressiva1.

Catalog No. NC0689818


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