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Medchemexpress LLC LDN-209929 dihydrochloride | 1784281-97-5 | 98.3% | 405.77 | 25 MG
SDP

Supplier:  Medchemexpress LLC 25MGHY110320

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LDN-209929 dihydrochloride is a potent and selective haspin kinase inhibitor (IC50=55 nM) with 180-fold selectivity versus DYRK2 (IC50=9.9 μM). It is an optimized analogue of LDN-192960.

  • Potent and selective haspin kinase inhibitor (IC50=55 nM)
  • 180-fold selectivity versus DYRK2 (IC50=9.9 μM)
  • Optimized analogue of LDN-192960
  • Haspin (Haploid Germ Cell-Specific Nuclear Protein Kinase) is a serine/threonine kinase expressed in various tissues and plays a role in mitosis by phosphorylating histone H3 at Thr-3 (H3T3)
  • DYRKs belong to the CMGC family of ePKs and their activity depends on autophosphorylation of an essential activation loop tyrosine

Catalog No. 50-003-45766


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