Apexbio Technology LLC LDN-212854 1432597-26-6 10mM (in 1mL DMSO)

Supplier:  Apexbio Technology LLC B36875.1

LDN-212854 (CAS 1432597-26-6) is a highly selective inhibitor of the bone morphogenetic protein (BMP) signaling pathway targeting ALK2 with an IC50 of 1 2 nM In kinase assays LDN-212854 demonstrates potent inhibition of constitutively active ALK2 (caALK2 IC50 16 nM) and displays substantially reduced activity against caALK5 (IC50 2 M) indicative of its BMP pathway selectivity over TGF- signaling Compared to caALK1 and caALK3 its inhibitory activity against caALK2 is 6- and 10-fold greater respectively In BMP receptor-transfected C2C12 cell models LDN-212854 preferentially inhibits caALK2-mediated signaling In transgenic models of heterotopic ossification treatment with LDN-212854 reduces ectopic bone formation This compound is a valuable tool for dissecting BMP/ALK2-driven signaling in cellular and in vivo studies

Catalog No. 50-000-90740