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Apexbio Technology LLC LDN 57444 668467-91-2 50mg
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Supplier:  Apexbio Technology LLC A400350

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LDN 57444 (CAS 668467-91-2) is a reversible competitive inhibitor of ubiquitin C-terminal hydrolase-L1 (Uch-L1) displaying an IC50 of 0 88 M It also inhibits Uch-L3 with lower potency (IC50 25 M) In neuronal systems Uch-L1 inhibition by LDN 57444 results in reduced long-term potentiation and basal synaptic transmission effects resembling -amyloid-induced synaptic impairment Additionally in the rat insulinoma cell line INS 832/13 LDN 57444 triggers apoptosis characterized by increased caspase-3 activity and enhanced nuclear CHOP expression suggesting ER-stress associated cell death mechanisms This compound is utilized in neuroscience and cell biology research to investigate ubiquitin pathway modulation and related cellular responses

Catalog No. 50-000-63960


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