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Medchemexpress LLC Leonurine hydrochloride | 24735-18-0 | 347.79 | 100 MG
Supplier: Medchemexpress LLC HYN0741A100MG
Leonurine hydrochloride is an alkaloid isolated from Leonurus artemisia, exhibiting anti-oxidative and anti-inflammatory properties. This compound is intended for research use only, playing a role in various biological activities in vitro and in vivo.
- Causes diminution in lipid accumulation and cellular cholesterol content.
- Increases apoA-I- or HDL-mediated cholesterol efflux.
- Significantly increases the expressions of ABCA1 and ABCG1.
- Shows protective effects on cell viability of HepG2 and HL-7702 cells.
- Improves cellular lipid accumulation via activating AMPK/SREBP1 pathway.
- Inhibits the expression of iNOS, COX-2, PGE2, NO, TNF-α, and IL-6.
- Suppresses ECM degradation in human OA chondrocytes.
- Blocks IL-1β-induced PI3K and Akt phosphorylation.
- Ameliorates osteoarthritis development in mouse DMM model.
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