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Enzo Life Sciences Leptomycin B (100µg). CAS: 87081-35-4
Supplier: Enzo Life Sciences ALX380100C100
A potent and specific nuclear export inhibitor. Leptomycin B alkylates and inhibits CRM1/exportin 1, a protein required for nuclear export of proteins containing a nuclear export sequence (NES). In addition to antifungal and antibacterial activities, blocks the cell cycle and is a potent anti-tumor agent. At low nM concentrations, blocks the nuclear export of many proteins including HIV-1 Rev, MAPK/ERK, and NF-κB/IκB and it stabilizes the expression of p53. Other proteins that are influenced by leptomycin B are actin, c-Abl, cyclin B1, MDM2/p53, Iκb, MPF and PKA. Leptomycin B also inhibits the export and translation of many RNAs, including COX-2 and c-Fos mRNAs, by inhibiting export of ribonucleoproteins. Alternative name: LMB. Formulation: Solution in 100% ethanol. Purity: ≥96% (HPLC). Appearance: Liquid. Solubility: Soluble in methanol or 100% ethanol; insoluble in water. Unstable in DMSO. Long Term Storage: -20°C.
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