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Medchemexpress LLC Lesogaberan (hydrochloride) | 2925644-17-1 | 98.0% | 177.54 | 5 MG
Supplier: Medchemexpress LLC 5MGHY10061B
Lesogaberan (AZD-3355) hydrochloride is a potent and selective GABAB receptor agonist, with an EC50 of 8.6 nM for human recombinant GABAB receptors. It demonstrates high affinity for rat GABAB receptors (Ki: 5.1 nM) and inhibits transient lower esophageal sphincter relaxation through a peripheral mode of action. This compound has been shown to enhance human islet cell proliferation in vitro and protect human islet β-cells from apoptosis in islet grafts in mice. Lesogaberan hydrochloride exhibits high oral availability (88% in dogs, 100% in rats) and relatively low systemic clearance in rats, making it suitable for research applications.
- Potent and selective GABAB receptor agonist
- Inhibits transient lower esophageal sphincter relaxation
- Enhances human islet cell proliferation in vitro
- Protects human islet β-cells from apoptosis in islet grafts in mice
- High oral availability and low systemic clearance
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