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Apexbio Technology LLC Letrozole 112809-51-5 100mg
Supplier: Apexbio Technology LLC A1307100
Letrozole (CAS 112809-51-5) is a nonsteroidal reversible type II aromatase inhibitor that exhibits an IC50 of 11 5 nM It interacts with aromatase by coordinating to the heme iron within the cytochrome P450 complex via its 1 2 4-triazole moiety and a heterocyclic pyrrole component thereby inhibiting estrogen biosynthesis without affecting adrenal corticosteroids In research models letrozole has been shown to reduce synaptic and axonal growth in the spinal cord downregulate estrogen receptor expression and impact synaptic proteins such as GAP-43 with implications for neuroendocrine regulation and memory It is frequently used to investigate estrogen signaling and feedback mechanisms in reproductive and neurobiological studies
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