Cayman Chemical LeucetIn L41 10mg

Supplier:  Cayman Chemical 2922510 MG

An inhibitor of DYRK1A, DYRK2, CLK1, and CLK3 (IC50s = 0.04, 0.035, 0.015, and 4.5 µM, respectively); an inhibitor of GSK3α/β and Pim1 (IC50s = 0.41and 4.1 µM, respectively); inhibits TNF-α-induced SRp75 and SRp55 phosphorylation in human microvascular endothelial cells at 0.1-10 µM; modulates alternative pre-RNA splicing of a synthetic CLK1 minigene; prevents amyloid-β 25-35-induced lipid peroxidation and ROS accumulation in the hippocampus in a mouse model of Alzheimer’s disease-like toxicity; prevents amyloid-β 25-35-induced memory deficits in the same model at 0.4, 1.2, and 4 UG

Catalog No. 50-293-7189