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Apexbio Technology LLC Leukadherin 1 344897-95-6 200mg
Supplier: Apexbio Technology LLC B5770200
Leukadherin 1 (CAS 344897-95-6) is a small molecule agonist of the integrin CD11b/CD18 a cell surface adhesion receptor predominantly expressed on innate immune cells By activating CD11b/CD18 Leukadherin 1 enhances cell adhesion to fibrinogen with an EC50 of 4 M and increases CD11b/CD18-mediated adhesion to ICAM-1 In cellular models such as K562 cells it promotes membrane tether formation facilitating integrin-ligand interactions In vivo Leukadherin 1 reduces neutrophil accumulation in mouse models of acute peritonitis and decreases leukocyte infiltration and tissue injury in models of kidney transplantation and hyperoxia-induced lung injury This compound serves as a research tool for investigating integrin-mediated leukocyte functions and inflammatory processes
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