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AdipoGen anti-Lewisy/b hapten (human), mAb (SC104) (preservative free) (100 µg)
Supplier: AdipoGen AG20B6002PFC100
Monoclonal Antibody. Recognizes human sialyltetraosylceramide. Does not bind to blood lympocytes, granulocytes, bone marrow progenitor cells, GM1, GD1a, GT1b or sialyl LewisX antigens. Isotype: Mouse IgG1. Clone: SC104. Applications: ELISA, FACS, FUNC (Blocking), ICC, IHC. Liquid. In PBS. Lewis-y/b is a cell surface carbohydrate blood group antigen expressed at very low levels in normal tissue, but often found to be overexpressed on breast, lung, colon and ovarian cancer cells. Clone SC104 recognizes a unique cell surface antigen sialyltetraosylceramide, expressed by 90% of colorectal tumors at all clinical stages. SC104 targets colorectal cancer-associated glycolipids and induces tumor cell death in vitro independently of CDC or ADCC or blockade of known survival signaling pathways. It induces apoptotic cell death and synergizes with chemotherapy in vivo in mice.
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