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Medchemexpress LLC Lewis y tetrasaccharide | 82993-43-9 | 675.63 | 1 MG
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Supplier:  Medchemexpress LLC HYN105351MG

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Lewis Y tetrasaccharide (Lewis Y, LeY) is a tetrasaccharide derivative of Lewis X trisaccharide. It is an antigen associated with malignant ovarian carcinoma metastasis and poor prognosis. In vitro studies indicate its role in activating the FAK signaling pathway and upregulating Bcl-2/Bcl-XL expression, thereby enhancing cell adhesion-mediated drug resistance (CAM-DR) in ovarian cancer cells. It also leads to an increase in integrin α5β1 levels in ovarian carcinoma-derived cells that exhibit enhanced expression of LeY.

  • Enhances the adhesive and spreading potentials of ovarian carcinoma RMG-1 cells, mediated by integrin-fibronectin interaction.
  • Anti-LeY antibodies significantly inhibit the proliferation and adhesion ability of RMG-1-hFUT cells cultured in vivo.

Catalog No. 50-004-17050


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