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Apexbio Technology LLC LFM-A13 244240-24-2 200mg
Supplier: Apexbio Technology LLC B5952200
LFM-A13 (CAS 244240-24-2) is a small-molecule inhibitor targeting Bruton s tyrosine kinase (BTK) a cytoplasmic enzyme implicated in the signaling pathways regulating the growth and differentiation of B-lineage lymphoid cells LFM-A13 demonstrates high selectivity for BTK exhibiting an IC50 value of 17 2 M in kinase assays and shows minimal activity against other protein tyrosine kinases even at elevated concentrations In preclinical models LFM-A13 enhances the efficacy of standard chemotherapeutic regimens and increases survival rates in mice challenged with BCL-1 leukemia cells Currently LFM-A13 is under investigation in preclinical research settings
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