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Abcam LGK974, 1MG

Supplier:  Abcam AB2854041MG

Encompass_Preferred

MW 396.4 Da, Purity >=98%. LGK-974 is a potent and specific inhibitor of Porcupine (porcn), a Wnt-specific acyltransferase (IC₅₀ = ~0.4 nM). GK974 potently inhibits Wnt signaling, has strong efficacy in rodent tumor models, and is well-tolerated. In addition, head and neck cancer cell lines with loss-of-function mutations in the Notch signaling pathway have a high response rate to LGK974.

The product is subject to the following: Abcam Restricted Use Statement

Catalog No. 50-267-1249


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