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Medchemexpress LLC Lidocaine | 137-58-6 | 99.96% | 234.34 | 5 G
Supplier: Medchemexpress LLC 5GHYB0185
Lidocaine inhibits sodium channels involving complex voltage and dependence. It decreases growth, migration, and invasion of gastric carcinoma cells by up-regulating miR-145 expression and further inactivating MEK/ERK and NF-κB signaling pathways. As an amide derivative, it has potential for ventricular arrhythmia research.
- Inhibits sodium channels
- Decreases growth, migration, and invasion of gastric carcinoma cells
- Up-regulates miR-145 expression
- Inactivates MEK/ERK and NF-κB signaling pathways
- Causes reversible tail nerve block in rats
- Inhibits human TREK-1 in HEK293 cells
- Inhibits cell viability in human gastric cancer cell lines
- Increases apoptotic cell rate
- Down-regulates Cyclin D1 and up-regulates p21 expression
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