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AdipoGen LIF (human) (rec.) (3 x 10 µg)
SDP

Supplier:  AdipoGen AG40B00933010

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Protein. Human LIF (aa 23-202) is fused at the N-terminus to a tag. Source: E. coli. Endotoxin content: <0.05EU/µg purified protein (LAL test; Lonza). Lyophilized. Contains PBS. Mouse and human embryonic stem cells. Purity: >95% (SDS-PAGE). LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities also include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation and the stimulation of acute-phase protein synthesis in hepatocytes. LIF activates JAK & STAT signaling in human embryonic stem (ES) cells, but this pathway does not maintain pluripotency in these cells, which instead rely on FGF2-mediated ERK signaling. By contrast, mouse ES cells can be maintained by LIF-mediated JAK & STAT signaling.

Catalog No. 50-205-3156


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