LIGHT Detection Set (Risk Free), ProSci

Catalog No.	Quantity
16-595-561	1 Set

Catalog No. 16-595-561 Supplier ProSci LLC Supplier No. RF16060SET

Description

Mouse Monoclonal Detection Sets

LIGHT Monoclonal specifically detects LIGHT in Human samples. It is validated for ELISA, Western Blot, ICC, IHC-P, Flow, IF

LIGHT Antibody: LIGHT, also known as Tumor Necrosis Factor Superfamily member 14 (TNFSF14), is a co-stimulatory molecule that can regulate T-cell activation (1) and has recently been identified as an immune checkpoint protein. LIGHT binds to two different receptors, Herpes Virus Entry Mediator (HVEM) and Lymphotoxin beta Receptor (LTβR). While LIGHT binding to HVEM delivers a co-stimulatory signal to T cells (1), LIGHT binding to LTβR is critical for the formation of lymphoid structures which can stimulate T cell infiltration and activation of a tumor microenvironment, leading to rapid T cell-mediated tissue destruction (2). It has been shown that targeted delivery of LIGHT to tumors, thereby causing the T cell infiltration of the tumor, can enhance the response of the PD-1/PD-L1 checkpoint blockade anti-cancer therapy (3), suggesting that LIGHT may become a potent tool in anti-cancer treatment. ProSci's Risk-FreeTM antibodies are mouse monoclonal antibodies made to improve in vivo studies. Unlike antibodies developed using proteins made in yeast or bacteria, Risk-FreeTM antibodies are developed with antigens expressed in mammalian cell lines, giving the most native post-translational modifications to the protein. Validated for flow cytometry and ELISA Rigorously tested for the following applications: Immunoblot Immunohistochemistry Immunocytochemistry Immunofluorescence Multiple antibodies per target allowing the user to choose the best antibody for their application Available individually or as a set Risk-FreeTM means they are guaranteed to work for their approved applications

Specifications

• Antigen: LIGHT
• Applications: ELISA, Western Blot, Immunocytochemistry, Immunohistochemistry (Paraffin), Flow Cytometry, Immunofluorescence
• Concentration: Antibody 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS containing 0.02% sodium azide.
• Host Species: Mouse
• Immunogen: LIGHT antibodies were raised against the extracellular domain of human LIGHT.
• Purification Method: Antibodies are supplied as protein A purified IgG2b.
• Quantity: 1 Set
• Primary or Secondary: Primary
• Target Species: Human
• Content And Storage: Mouse Monoclonal: Antibodies can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Product Type: Detection Sets
• Form: Liquid
• Isotype: IgG2b