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Genscript Corporation LIGHT Human
Supplier: Genscript Corporation Z035601
LIGHT also known as tumor-necrosis factor (TNF) superfamily member 14 (TNFSF14) is predominantly expressed on activated immune cells and some tumor cells LIGHT (homologous to lymphotoxin exhibits inducible expression and competes with Herpes Simplex Virus glycoprotein D for Herpes Virus Entry Mediator a receptor expressed by T cells) is a protein primarily expressed on activated T cells activated Natural Killer (NK) cells and immature dendritic cells (DC) LIGHT can function as both a soluble and cell surface-bound type II membrane protein and must be in its homotrimeric form to interact with its two primary functional receptors Herpes Virus Entry Mediator (HVEM) and Lymphotoxin- Receptor (LT R) LIGHT signaling through these receptors have distinct functions that are cell-type dependent but interactions with both types of receptors have immune-related implications in tumor biology
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