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Cayman Chemical LIgnocerIc AcId-d3 5mg
SDP

Supplier:  Cayman Chemical 280845 MG

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A multi-kinase inhibitor inhibits EphB2 EphA3 Kit FMS VEGFR2/KDR FLT1 FGR Src Lyn BMX and Bcr-Abl in tyrosine kinase-transformed Ba/F3 cells (EC50s 50s 51 and 14 nM respectively) inhibits wild-type and mutant RET kinases (IC50s 24 7 94 2 and 15 8 nM for wild-type RETV804L and RETV804M respectively) reduces growth of NCI-H2286 and HCC-366 cancer cells (GI50s 0 51 and 0 65 M respectively) and RAT1 cells transformed by RETC634R or RETM918T (IC50s 44 and 56 nM respectively) inhibits tumor growth in vivo in a mouse PDX model of EphA2-overexpressing TNBC

Catalog No. 50-293-7932


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