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Genscript Corporation LILRA3/CD85eBiotin His Av
Supplier: Genscript Corporation Z04537500
Human LILRA3 also known as Leukocyte Ig-like receptor 4 (LIR-4) CD85 antigen-like family member E Immunogobulin-like transcript 6 (ILT-6) and monocyte inhibitory receptor HM43/HM31 is a 70 kD Ig superfamily member that belongs to the leukocyte receptor complex/cluster Mature LILRA3 is 416 amino acids (aa) in length and contains four C2-type Ig-like domains Unlike other LILR family members LILRA3 is actively secreted LILRA3 acts as soluble receptor for class I MHC antigens LILRA3 binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2 Binds with high affinity to the surface of monocytes leading to abolish LPS-induced TNF-alpha production by monocytes
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