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Medchemexpress LLC Limonin | 1180-71-4 | >98% | 470.51 | 1 ML
Supplier: Medchemexpress LLC HY1741110MM/1ML
Limonin is a natural product isolated from Dictamnus dasycarpus. It is known for its antiviral and antitumor activities, inhibiting HIV-1 and inducing apoptosis in human colon adenocarcinoma cells. In vitro studies show limonin's anti-proliferation effects on colon adenocarcinoma cells and pancreatic cancer cell lines, while in vivo research demonstrates its ability to significantly inhibit tumor growth in xenograft mouse models.
- Inhibits HIV-1 with an EC50 of 60.0 μM.
- Induces apoptosis in human colon adenocarcinoma cells with an IC50 of 54.74 μM.
- Shows anti-proliferation effects on Caco-2 and HCT-116 cells.
- Suppresses cell migration and invasion in HCT-116 cells.
- Activates Erk and p38 MAPK pathways.
- Significantly inhibits tumor growth in HCT-116 xenograft mouse models.
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