Lincomycin hydrochloride

Description

Lincomycin hydrochloride, CAS # 859-18-7, is a compound showing antibacterial activity against a wide variety of bacteria, including Staphylococcal, Streptococcal, and Bacteroides fragilis infections. It also shows inhibitory activity against protein synthesis. | CAS: 859-18-7 | C18H35ClN2O6S | 442.996 g/mol

Lincomycin hydrochloride is used to study the inhibition of protein synthesis, bacterial antibiotic resistance and protein and surfactant binding. It has been used in the treatment of Staphylococcal, Streptococcal, and Bacterioides fragilis infections.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Lincomycin hydrochloride is a lincosamide compound with antibacterial activity originally identified in the actinomycete, Streptomyces lincolnensis, with activity against gram-positive cocci and anaerobic bacteria
• Lincomycin inhibits bacterial protein synthesis by forming cross-links within the peptidyl transferase loop region of the 23S rRNA

Application

• Lincomycin hydrochloride is commonly used to study the inhibition of protein synthesis, bacterial antibiotic resistance, and protein and surfactant binding
• It has been used against Staphylococcal, Streptococcal, and Bacteroides fragilis species
• It is protective against the development of mastitis in a mouse model of acute mastitis induced by S. aureus

Specifications

Chemical Identifiers

• CAS: 859-18-7
• Molecular Formula: C18H35ClN2O6S
• Molecular Weight (g/mol): 442.996
• MDL Number: MFCD00058237
• InChI Key: POUMFISTNHIPTI-OXVORJCQSA-N
• PubChem CID: 124080936
• IUPAC Name: (2R,4R)-N-[(1R,2R)-2-hydroxy-1-[(2S,3R,4S,5R,6S)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide;hydrochloride
• SMILES: CCCC1CC(N(C1)C)C(=O)NC(C2C(C(C(C(O2)SC)O)O)O)C(C)O.Cl

• Type: Lincomycin Hydrochloride
• Physical Form: Crystalline Powder
• Color: White
• Quantity: 1 g
• Beilstein: 4171650
• Solubility Information: Soluble in water
• Formula Weight: 443
• Chemical Name or Material: Lincomycin hydrochloride

Safety and Handling

Hazard Category	H315-H319-H335
Hazard Statement	GHS H Statement H315-H319-H335 Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statement	P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
EINECSNumber	212-726-7
RTECSNumber	RH6315000
TSCA	No
Recommended Storage	Keep cold

SDS

RUO – Research Use Only