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AdipoGen Lipofermata
Supplier: AdipoGen AGCR13542M050
Chemical. CAS 297180-15-5. Formula C15H10BrN3OS. MW 360.2. Lipofermata is an inhibitor of fatty acid transport, blocking fatty acid transport protein 2 FATP2, and was identified afterwards as a FATP1 inhibitor as well. Inhibition was specific for long and very long chain fatty acids but not medium C6-C10 fatty acids in myocytes mmC2C12, pancreatic beta cells rnINS-1E, intestinal epithelial cells hsCaco-2 and hepatocytes hsHepG2, as well as primary human adipocytes. The fatty acid transport proteins FATP, when localized to the plasma membrane or at intracellular membrane junctions with the endoplasmic reticulum, function as a gate in the regulated transport of fatty acids and thus represent a therapeutic target to delimit the acquisition of fatty acids that contribute to disease as in the case of fatty acid overload, such as obesity, Typ 2 diabetes or cancers.
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