Human lipopolysaccharide-binding protein (LBP) is a member of the BPI/LBP/Plunc superfamily detected in blood serum, playing a critical role in the innate immune response. This protein binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid found in the outer membrane of all Gram-negative bacteria, serving as an affinity enhancer for CD14 to facilitate its association with LPS. Furthermore, it promotes the release of cytokines in response to bacterial lipopolysaccharide. This product is expressed in HEK293 cells and contains a C-terminal polyhistidine tag.
- Greater than 95% purity determined by SDS-PAGE
- Calculated molecular weight of 52.8 kDa, migrating as 62 kDa under reducing conditions due to glycosylation
- Endotoxin level of less than 1.0 EU per μg
- Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4 with trehalose as a protectant