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Medchemexpress LLC Liproxstatin-1 | 950455-15-9 | 99.70% | 200 MG
Supplier: Medchemexpress LLC HY12726200MG
Liproxstatin-1 is identified as a potent ferroptosis inhibitor, effectively suppressing ferroptotic cell death with an IC50 value of 22 nM. It demonstrates anti-ferroptotic activity across various cell types, including fibroblasts, lymphocytes, and mouse embryonic fibroblasts (MEFs). Studies have also indicated its ability to suppress ferroptosis in vivo, specifically in human cells, Gpx4 deficient kidney cells, and in an ischemia/reperfusion-induced tissue injury model.
- Potent ferroptosis inhibitor.
- Inhibits ferroptotic cell death with an IC50 of 22 nM.
- Shows anti-ferroptotic activity in mouse embryonic fibroblasts with an IC50 of approximately 38 nM.
- Suppresses ferroptosis in human cells.
- Suppresses ferroptosis in Gpx4 deficient kidney.
- Suppresses ferroptosis in an ischemia/reperfusion-induced tissue injury model.
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