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Cayman Chemical LIrafugratInIb 10mg
Supplier: Cayman Chemical 4094010 MG
A covalent FGFR2 inhibitor (IC50 = 0.003 µM); selective for FGFR2 over FGFR1, -3, and -4 (IC50s = 0.77, 0.26, and 15 µM, respectively); inhibits the proliferation of SNU-16 cells (IC50 = 0.002 µM); reduces intratumoral FGFR2 phosphorylation and tumor volume in an FGFR2-amplified SNU-16 gastric cancer mouse xenograft model at 10 mg/kg
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