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Medchemexpress LLC Lith-O-Asp | 881179-02-8 | 98.0% | 491.66 | 100 MG
Supplier: Medchemexpress LLC HY112415100MG
Lith-O-Asp is a sialyltransferase (ST) inhibitor with IC50s of 12-37 μM. It inhibits the activities of ST3Gal I, ST3Gal III, and ST6GalI, decreasing the expression of cell surface α-2,3- and α-2,6-sialylated antigens.
- Inhibits sialyltransferase (ST) activities with IC50 values ranging from 12 to 37 μM.
- Decreases the activity of both α-2,3- and α-2,6-sialyltransferases.
- Inhibits the transfer of sialic acids to targeted glycoproteins.
- Shows no apparent growth inhibition effect toward different cancer cell lines at tested doses.
- Leads to fewer lung metastases in treated mice.
- Decreases average tumor nodules per mouse in vivo.
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