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Medchemexpress LLC Lithocholic acid 3-sulfate disodium | 64936-81-8 | 99.9% | 500.60 | 25 MG
SDP

Catalog No. 5000439998
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Lithocholic acid 3-sulfate disodium is a GPR39 agonist with EC50 values of 41 μM and 42.4 μM in M39-20 and hGPR39-2 cells, respectively, in the absence of Zn2+, and 0.88 μM and 0.97 μM in the presence of Zn2+. It also functions as a RORγt ligand, stimulating the GPR39 receptor to initiate intracellular calcium signaling independently of Zn2+-binding sites H17 and H19. LCA-3-S selectively inhibits Th17 cell differentiation by targeting RORγt and can be used in the research of cholestatic liver diseases.

  • Binds to the purified human RORγt LBD.
  • Activates intracellular calcium signaling induced by mutant (H17A and H19A) GPR39 in 293T cells.

Catalog No. 50-004-39998 Supplier Medchemexpress LLC Supplier No. 25MGHY113238A
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Lithocholic acid 3-sulfate disodium is a GPR39 agonist with EC50 values of 41 μM and 42.4 μM in M39-20 and hGPR39-2 cells, respectively, in the absence of Zn2+, and 0.88 μM and 0.97 μM in the presence of Zn2+. It also functions as a RORγt ligand, stimulating the GPR39 receptor to initiate intracellular calcium signaling independently of Zn2+-binding sites H17 and H19. LCA-3-S selectively inhibits Th17 cell differentiation by targeting RORγt and can be used in the research of cholestatic liver diseases.

  • Binds to the purified human RORγt LBD.
  • Activates intracellular calcium signaling induced by mutant (H17A and H19A) GPR39 in 293T cells.

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