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Medchemexpress LLC LL-K8-22 | 99.1% | 573.77 | 5 MG
SDP

Supplier:  Medchemexpress LLC HY1492095MG

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LL-K8-22 is a potent, selective, and durable PROTAC CDK8-cyclin C dual degrader, exhibiting DC50 values of 2.52 and 2.64 μM respectively. It effectively suppresses STAT1 Ser 727 phosphorylation and inhibits E2F- and MYC-driven carcinogenic transcriptional programs. This compound is suitable for research pertaining to triple-negative breast cancer (TNBC).

  • Functions as a potent, selective, and durable PROTAC CDK8-cyclin C dual degrader.
  • Suppresses STAT1 Ser 727 phosphorylation.
  • Inhibits E2F- and MYC-driven carcinogenic transcriptional programs.
  • Applicable for triple-negative breast cancer (TNBC) research.
  • Suppresses tumor cell proliferation in vitro.
  • Selectively degrades CDK8 without affecting CDK19 or other cyclin proteins, except cyclin C.

Catalog No. 50-003-61200


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