Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. 5000403766

Medchemexpress LLC LM10 | 1316695-35-8 | 99.9% | 229.22 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY33298100MG

Encompass_Preferred

LM10 is a potent inhibitor of tryptophan 2,3-dioxygenase (TDO). Tryptophan 2,3-dioxygenase (TDO) is an unrelated hepatic enzyme that also degrades tryptophan along the kynurenine pathway. LM10 has the potential for the research of cancer diseases.

  • Prevents the growth of TDO-expressing P815 tumor cells and promotes better rejection of control clone P815B cl1, which does not express TDO.
  • Displays a good TDO inhibition (Ki = 5.6 μM) with a competitive inhibition profile.
  • Does not inhibit IDO and has a high solubility and bioavailability without obvious signs of toxicity.
  • The plasma concentration after oral administration is about 40 times above the IC50 measured in the cellular assay performed with the physiological concentration of plasma tryptophan.

Catalog No. 50-004-03766


May include imposed supplier surcharges.
Only null left
Add to Cart

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.