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Medchemexpress LLC LM11A-31 dihydrochloride | 1243259-19-9 | 99.9% | 316.27 | 10 MG
Supplier: Medchemexpress LLC HY11015510MG
LM11A-31 dihydrochloride is a non-peptide p75NTR (neurotrophin receptor p75) modulator and an orally active, potent proNGF (nerve growth factor) antagonist. It is an amino acid derivative with high blood-brain barrier permeability that blocks p75-mediated cell death. This compound reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models at mid- to late-stage disease progression. It is for research use only.
- Non-peptide p75NTR modulator
- Orally active and potent proNGF antagonist
- Amino acid derivative
- High blood-brain barrier permeability
- Blocks p75-mediated cell death
- Reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models
- Mitigates proNGF accumulation and preserves BRB integrity (in vivo)
- Prevents and/or reverses atrophy of basal forebrain cholinergic neurites and cortical dystrophic neurites in mid-stage male APPL/S mice (in vivo)
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