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Medchemexpress LLC LM11A-31 (dihydrochloride) | 1243259-19-9 | 99.9% | 316.27 | 25 MG
Supplier: Medchemexpress LLC 25MGHY110155
LM11A-31 dihydrochloride is a non-peptide p75NTR (neurotrophin receptor p75) modulator and an orally active, potent proNGF (nerve growth factor) antagonist. It is an amino acid derivative that readily crosses the blood-brain barrier and inhibits p75-mediated cell death. This compound has been shown to reverse cholinergic neurite dystrophy in mouse models of Alzheimer's disease during mid- to late-stage disease progression. It is intended for research use only and is not sold to patients.
- Non-peptide p75NTR modulator
- Orally active and potent proNGF antagonist
- Amino acid derivative with high blood-brain barrier permeability
- Blocks p75-mediated cell death
- Reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models
- Mitigates proNGF accumulation and preserves BRB integrity in animal models
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