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Apexbio Technology LLC LMK 235 1418033-25-6 10mM (in 1mL DMSO)
SDP

Supplier:  Apexbio Technology LLC A44945.1

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LMK 235 (CAS 1418033-25-6) is a histone deacetylase (HDAC) inhibitor exhibiting preferential selectivity against HDAC4 and HDAC5 isoforms HDAC enzymes (EC 3 5 1 98) catalyze the removal of acetyl groups from lysine residues on histone proteins influencing DNA-histone interactions and gene expression In vitro LMK 235 demonstrates potent inhibition at nanomolar concentrations against HDAC4/5 and notable cytotoxic effects toward multiple cancer cell lines including A2780 Cal27 Kyse510 and MDA-MB231 In animal studies LMK 235 enhances the antitumor efficacy of cytarabine suggesting applications in overcoming chemoresistance in leukemia models Currently LMK 235 remains under preclinical investigation

Catalog No. 50-000-62470


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