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  10. LMK 235, Tocris Bioscience™ 

LMK 235, Tocris Bioscience™ Available on GSA/VA Contract for Federal Government customers only.

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Quantity:
10mg
50mg
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1418033-25-6
C15H22N2O4
294.351
VRYZCEONIWEUAV-UHFFFAOYSA-N
6-3,5-dimethylphenyl formamido oxy-n-hydroxyhexanamide,n-6-hydroxyamino-6-oxohexyl oxy-3,5-dimethylbenzamide,n-5-hydroxycarbamoyl pentoxy-3,5-dimethylbenzamide,n-6-hydroxyamino-6-oxo-hexoxy-3,5-dimethyl-benzamide,n-6-hydroxyamino-6-oxohexyl oxy-3,5-dimethyl-benzamide
71520717
N-[6-(hydroxyamino)-6-oxohexoxy]-3,5-dimethylbenzamide
CC1=CC(=CC(=C1)C(=O)NOCCCCCC(=O)NO)C
This item is not returnable. View return policy
1418033-25-6
C15H22N2O4
294.351
VRYZCEONIWEUAV-UHFFFAOYSA-N
6-3,5-dimethylphenyl formamido oxy-n-hydroxyhexanamide,n-6-hydroxyamino-6-oxohexyl oxy-3,5-dimethylbenzamide,n-5-hydroxycarbamoyl pentoxy-3,5-dimethylbenzamide,n-6-hydroxyamino-6-oxo-hexoxy-3,5-dimethyl-benzamide,n-6-hydroxyamino-6-oxohexyl oxy-3,5-dimethyl-benzamide
71520717
N-[6-(hydroxyamino)-6-oxohexoxy]-3,5-dimethylbenzamide
CC1=CC(=CC(=C1)C(=O)NOCCCCCC(=O)NO)C

Description

Selective HDAC4/HDAC5 inhibitor

Selective histone deacetylase (HDAC) 4 and HDAC5 inhibitor (IC50 values are 4.22, 11.9, 55.7, 320, 852, 881, and 1278 nM for HDAC 5, 4, 6, 1, 11, 2, and 8, respectively). Demonstrates activity against chemoresistant cancer cell lines in an MTT assay for cytotoxicity using human ovarian cancer cell lines A2780 and cisplatin resistant A2780CisR (IC50 = 0.49 and 0.32 μM respectively).

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Quantity 10mg
Formula Weight 294.35
Percent Purity >98%
Chemical Name or Material LMK 235

Safety and Handling

Recommended Storage : Store at -20°C