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Cayman Chemical LMWPTP InhIbItr Ihydrochl 25mg
Supplier: Cayman Chemical 2227725 MG
An inhibitor of LMW-PTPA (IC50 = 0.8 µM); selective for LMW-PTPA over a panel of 15 protein tyrosine phosphatases but does inhibit LMW-PTPB activity by >50% at 40 µM; increases insulin-induced insulin receptor phosphorylation in HepG2 cells at 10 µM; improves glucose tolerance and decreases fasting plasma insulin levels in a mouse model of diet-induced obesity at 50 mg/kg per day
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