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Medchemexpress LLC Lobeglitazone sulfate | 763108-62-9 | 99.6% | 578.61 | 100 MG
Supplier: Medchemexpress LLC HY14928A100MG
Lobeglitazone sulfate is a novel thiazolidinedione and an orally active agonist for PPAR with EC50 values of 137.4 nM for PPARγ and 546.3 nM for PPARα. It acts as an inhibitor for the ERK/JNK/Smad/NF-κB signaling pathway.
- Exhibits anti-inflammatory, anti-diabetic, anti-fibrotic, and anti-atherosclerotic properties.
- Increases glucose uptake in 3T3-L1 adipocytes and L6 muscle cells.
- Inhibits NO generation and pro-inflammatory cytokines in LPS-stimulated BMDMs.
- Inhibits TGF-β1-induced expression of α-SMA and fibronectin, showing anti-fibrotic properties.
- Inhibits PDGF-induced proliferation and migration of vascular smooth muscle cells.
- Demonstrates anti-atherosclerotic property in ApoE-/- mouse aortic atherosclerosis models.
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