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Medchemexpress LLC Lobeglitazone (sulfate) | 763108-62-9 | 99.6% | 578.61 | 25 MG
Supplier: Medchemexpress LLC 25MGHY14928A
Lobeglitazone sulfate is a new type of thiazolidinedione, acting as an orally active agonist for PPARγ and PPARα. It inhibits the ERK/JNK/Smad/NF-κB signaling pathway and possesses various therapeutic properties.
- Agonist for PPARγ (EC50 of 137.4 nM) and PPARα (EC50 of 546.3 nM)
- Inhibits ERK/JNK/Smad/NF-κB signaling pathway
- Exhibits anti-inflammatory, anti-diabetic, anti-fibrotic, and anti-atherosclerotic properties
- Increases glucose uptake in 3T3-L1 adipocytes and L6 muscle cells
- Inhibits NO generation and pro-inflammatory cytokines in LPS-stimulated BMDMs
- Inhibits TGF-β1-induced expression of α-SMA and fibronectin
- Inhibits PDGF-induced proliferation and migration of vascular smooth muscle cells
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