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Medchemexpress LLC Lobeglitazone (sulfate) | 763108-62-9 | 99.6% | 578.61 | 5 MG
Supplier: Medchemexpress LLC HY14928A5MG
Lobeglitazone sulfate is a novel thiazolidinedione, functioning as an orally active agonist for PPAR with EC50 values of 137.4 nM for PPARγ and 546.3 nM for PPARα. It acts as an inhibitor for the ERK/JNK/Smad/NF-κB signaling pathway, demonstrating anti-inflammatory, anti-diabetic, anti-fibrotic, and anti-atherosclerotic properties.
- Functions as an orally active agonist for PPAR
- Inhibits ERK/JNK/Smad/NF-κB signaling pathway
- Exhibits anti-inflammatory properties
- Exhibits anti-diabetic properties
- Exhibits anti-fibrotic properties
- Exhibits anti-atherosclerotic properties
- Increases glucose uptake in 3T3-L1 adipocytes and L6 muscle cells
- Inhibits NO generation and pro-inflammatory cytokine expression
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